A type of nerve pain brought by chronic irregular levels of blood glucose accompanied by the absence of enough circulation to the organ systems and extremities of the body is called diabetic neuropathy. Individuals suffering from this form of neuropathy usually experience dull, shooting and sharp numbing pains. In worst cases, it could result to complete numbness.
How can CBD help with diabetic neuropathy?
There are currently no clinical trials done to examine the effects of cannabidiol (CBD) for diabetic neuropathy. This only means that the potential health benefits of CBD in treating the condition are merely based on speculative research performed largely with cultured nerve cells or animal models.
Nevertheless, CBD’s analgesic and neuroprotectant properties are widely known and well documented in the past years. The US government has, in fact, held a patent on the cannabis compound for its neuroprotective potential from disease-induced degeneration and cell damages.
In this regard, some physicians and researchers speculate that a premium CBD oil could be able to protect nerve cells from neuropathic pains induced by diabetes, and could even reverse emerging damage. Truly, the limited research that has been conducted so far seems to back up this hypothesis.
According to a 2012 publication in the Journal of Experimental Medicine, CBD was shown to suppress both pain and inflammation induced by neuropathy.
By observing CBD effects on regulating pain in rat nerve cells, the study found that the active compound serves as a pain reliever for pains related to neuropathy.
The study concluded that the intrathecal and systemic administration of CBD and its modified derivatives considerably inhibit neuropathic pain and chronic inflammation without inducing analgesic tolerance among mice.
Simply put, the non-psychoactive compound from marijuana plant significantly reduced pain related to neuropathy without causing any adverse tolerance form to the cannabinoid. This is among the major concerns in taking opioids and other prescribed neuropathy pain relievers.
A study published in Current Neuropharmacology in 2006 has shown the therapeutic value of cannabinoid receptors against neuropathy. It was, in essence, a review of current research done on cannabis extracts such as CBD and THC, as well as the role they take in treating all forms of pain, including those induced by neuropathy. So as to develop a clearer perspective on how the physiological pathway exactly works, the study noted that advanced double-blind, placebo-controlled clinical trials may be deemed necessary.
A study published in Therapeutics and Clinical Risk Management in 2008, meanwhile, observed CBD’s role in managing chronic pain. This is yet another study which reviewed already-completed research and several studies on general pain management’s role of cannabinoids involving randomized clinical trials. Investigators said that various randomized clinical trials have shown the efficacy and safety of an FDA approved medication derived from cannabis called Sativex, in treating cancer pain, rheumatoid arthritis, and central and peripheral neuropathic pain.
While Sativex is essentially a cannabinoid that is packaged and branded, it must, in theory, demonstrate several therapeutic benefits as natural cannabinoids, such as CBD oil and THC.
A study published in Phytotherapy Research in 2008 has shown that cannabis extract has analgesic properties against neuropathic pain among rodents. It particularly aimed at getting a bit more complex and at trying to determine several of the physiological or chemical mechanisms which are involved in managing neuropathic pain from cannabinoid-based treatment. The study found that cannabis extract containing many cannabinoids have better pain relieving (antinociceptive) effectiveness than a single cannabinoid administered individually when tested among rodents.
Simply put, the study confirmed that while CBD is effective in treating neuropathic pain, a full spectrum cannabis extract containing CBD, flavonoids, terpenes and other natural cannabinoids are a lot more effective. Other studies have likewise validated this and are called the “entourage effect.”