The nervous system, composed of a complex chain of neurons, is behind our perception of pain. It is responsible for communicating with other parts of our body. It is comprised of two parts: (a) the central nervous system that is composed of the spinal cord and the brain; (b) and the peripheral system that is made of nerves and nerves and nerve pathways spread across the body and the limbs. Pain arises whenever a part of the system is damaged. Symptoms like tingling and burning sensations occur in the peripheral system, especially in the limbs. Numbness happens when the nerves fail to transmit signals. This is called neuropathy in clinical terms. There are several forms of neuropathy as there are as many factors causing it. Diabetes-related peripheral neuropathy is the most diagnosed cause.
Diabetes occurs with long-term hyperglycemia which causes increases reactive oxygen species (ROS), and downstream metabolic cascades of advanced glycation end‐products (AGE)/receptor for AGE (RAGE) reactions and polyol pathway hyperactivity. Through the activation of nuclear factor‐(NF)‐κB, an increase in mitogen‐activated protein kinase (MAPK), alterations of protein kinase C (PKC), and activation of the poly‐ADP‐ribose polymerase (PARP), the neural tissues and endoneurial microvessels are compromised. They all result in structural and functional changes of peripheral neuropathy. Meanwhile, the migration of macrophages, suppression of neurotrophins and the release of cytokines are all induced by pro‐inflammatory reactions as brought by metabolic abnormalities in the nerve. These, on the other hand, promote neuropathy development. Simply put, all these activities result in inflammation and pain.
Currently, while there are a lot of treatment options available for neuropathy such as anticonvulsants, anti-depressants, and opioids, their success rate is limited. Moreover, they come with adverse effects.
As a result, a lot of people are searching for an alternative solution while some are coming out to testify the effectiveness of cannabis in making them feel better.
While you may be wondering how this plant can aid in treating nerve damage, medical studies have found it containing analgesic, anti-inflammatory, neuroprotector, and nuerogenerator properties. It was also found to inhibit the production of cytokines and NF-kb. In doing so, they reduce nociceptive pain and inflammation.
A particular compound from the cannabis plant, known as cannabidiol (CBD) was found to protect the myelin sheath covering the nerve. This non-psychoactive compound likewise serves as a “neuroprotective agent” via various mechanisms, like attenuating glial activation, reducing oxidative stress, and normalizing glutamate homeostasis.
What’s the best ratio of cannabis to treat neuropathy?
A lot of people are found to respond well to a high ratio of CBD like 1:20 or a 1:40. Adding a minimal amount of psychoactive compound THC increases the effect of both compounds and results in synergy.
Studies show that high level of CBD lowers down inflammation and reduces cytokine production. It is best to use the compound during the day as it does not inhibit short-term memory or disorient you.
If you wish to alter the body’s pain perception, a high THC ratio of 20:1 will work well. Imagine THC as you rescuer while CBD as your regulator. To circumvent THC’s psychoactive properties from disrupting your daily routines like concentrating or driving, THC is allocated at night. In doing so, in case unpleasant side effects take place, you may simply need to go to bed and doze the high off. Another obvious reason why a high THC ratio is used at night is that the psychoactive compound likewise aids individuals to sleep.
When dealing with neuropathies, it is important to make sure you receive both THC and CBD. The latter is quite vital to nerve issues. Considering that a lot of nerve issues happen because of glutamate and GABA being out of balance, normalizing glutamate homeostasis is important in bringing signaling transmission into regulation. One may feel reduced nerve pain by having healthy glutamate and GABA transmissions since signaling is appropriately functioning.